Emmanuel Lewis was born March 9th, 1971 in Brooklyn, New York. The youngest son of Margaret Lewis, a former computer-science professional, Emmanuel attended regular public schools in Brooklyn until his busy acting career took him to Hollywood. He has four siblings. His acting career began one day when he was jogging with an actor-friend who asked him if he wanted to be in the business. The friend suggested that Emmanuel's mother contact the Shuller Talent Agency, which handles gifted children for TV commercials. He thought that Emmanuel had the perfect face and personality for commercials. The friend proved right. Emmanuel was signed by the agency the minute the agents saw him and before long he was appearing in commercials for such products as fruit juice, cars, stereos, glue, soup, toys, coffee, pudding, pizza, and, of course, Burger King. He did around 50-60 commercials including one for Campbell's Soup and Life Cereal and the 4 Burger King commercials. His Colgate commercial can be seen in the movie 'Splash' when Madison (the mermaid) goes to the mall (it can be seen on the TVs in the background).

The first acting job Emmanuel had that wasn't in a commercial was the part of The Changeling Boy in the Joseph Papp New York Shakespeare Festival Production of A Midsummer Night's Dream. Emmanuel also guest-starred on such TV talk shows as "The Tonight Show" and "The Phil Donahue Show" but "Webster" was Emmanuel's first major role on a TV series.