As a solo artist, Timberlake has often collaborated with the Black Eyed Peas, receiving an Grammy nomination with the band for "Where Is The Love?" He has also worked with Nelly, Snoop Dogg and Nelly Furtado and started his own record company, JayTee Records, in 2005. The following year, he released his second solo album, FutureSex/LoveSounds, which debuted at No. 1 on the Billboard chart. The album's lead single, "SexyBack", spent several consecutive weeks at No. 1. In 2008, Timberlake helped make Madonna’s single, “4 Minutes,” a top ten hit. Not only did he provide some of the vocals, he was also a co-writer of the song. Timberlake also contributed to several other tracks on Madonna’s Hard Candy album.

Also pursuing an acting career, Timberlake has experienced limited success. While parts in Alpha Dog (2006) and Black Snake Moan (2006) garnered little notice, he did hit it big as the voice for a young King Arthur in 2007’s smash animated film Shrek the Third, which featured Mike Myers as the title character. Timberlake continues to seek out new roles. Reteaming with Myers, he appeared in the 2008 comedy The Love Guru. He will also appear in the upcoming drama The Open Road with Jeff Bridges and Mary Steenburgen. In addition to acting, Timberlake has also opened several restaurants, started a clothing line and participated in humanitarian efforts in his native Tennessee.

Timberlake once dated fellow pop singer Britney Spears and actress Cameron Diaz. He is currently romantically linked to actress Jessica Biel.