DNA Lounge is a popular late-night San Francisco nightclub in the SoMa district, owned by celebrated hacker Jamie Zawinski. The club features DJ dancing, live music, burlesque performances, and occasionally conferences, private parties, and film premieres. It is located at 375 Eleventh Street, near Harrison Street.

The club maintains several unconventional features, including several publicly accessible internet terminals, an open wireless network, and a large scrolling LED sign with a publicly accessible web interface. The club also provides continuous audio and video webcasts of all events, for free.