TPAC is located in the James K. Polk Cultural Center at 505 Deaderick Street in downtown Nashville, occupying an entire city block between 5th and 6th Avenues and Deaderick and Union Streets. Also housing the Tennessee State Museum, the cultural center adjoins the 18 story James K. Polk Office Tower.

The performance venues at TPAC are Andrew Jackson Hall (2,472 seats), James K. Polk Theater (1,075), Andrew Johnson Theater (256) and War Memorial Auditorium (1,661), the historic landmark located across 6th Avenue and the plaza from the Center. Among its many operations, TPAC presents a series of Broadway shows and special engagements, and administers a comprehensive education program.

TPAC is also home to three resident performing arts organizations: Nashville Ballet, Nashville Opera, and Tennessee Repertory Theatre. Presenting their work on the stages of TPAC, all of these organizations are independent of the center.