Their first single was "Easy Love", released in 2006. They released their second single, "Work On You", on July 6. In contrast to the "Easy Love" music video, "Work On You" featured animated robots similar to those found in classic cartoons (see: Voltron, Transformers ). Although The Looks is MSTRKRFT's first album featuring original content, the band has created remixes from a variety of other artists ranging from Buck 65 to The Kills to Jesse F. Keeler's own band, Death from Above 1979.
MSTRKRFT released their first LP, The Looks, on July 18, 2006 in the United States and February 2, 2007 in Britain. Keeler and Al-P told Eye Weekly weeks before the release of The Looks, that as the album was being finished, the planning stages for a follow-up record had already begun. Describing the upcoming album's new direction, Al-P said that the album would be "darker, underground disco and house with elements of American rock music."
The "2007" version of their song "Street Justice" was also released as a single. On the band's website message board, Keeler mentioned they were also working on a compilation album composed of their remixed tracks. Street Justice was also featured on the THQ action game, Saints Row 2. Neon Knights was also featured on Need For Speed: Pro Street, and their remix for Justices' D.A.N.C.E. was featured on the movie "Meet The Spartans".
Their song "Paris" was featured in a 2006 commercial for the online music store URGE. In 2007 MSTRKRFT appeared at the WEMF World Electronic Music Festival.
In September 2007 MSTRKRFT performed at an Australian spring music festival "Parklife" in Brisbane. They performed their remix of the song "Woman" from Modular label mates Wolfmother. Andrew Stockdale of Wolfmother appeared on stage and sang live while MSTRKRFT performed the remix.
In 2008 through Obeygiant.com released a mix cd with Z-Trip. In conjunction with this CD, Obey offered the Art work print, entitled Soundclash of the Titans. On May 24, 2008 MSTRKRFT were featured on the famous BBC Radio 1 show, The Essential Mix. MSTRKRFT later performed at the 2008 Bonnaroo Music and Arts Festival, which included a diverse group of artists ranging from Metallica to Jack Johnson.
On March 17, 2009, MSTRKRFT released their second LP, titled Fist of God. All songs were written by Jesse F. Keeler and Al-P. Initial critical response has been average at best, with major periodicals Spin, Rolling Stone, and Blender giving the album less-than-stellar reviews. The album features guest appearances by John Legend, E-40, N.O.R.E., and Lil' Mo, among others.